By Vincent J. Cristofalo PhD

ISBN-10: 0826164927

ISBN-13: 9780826164926

This quantity provides a transparent, concise evaluation of the present country of information concerning the biology of getting older ñ serving as either a useful graduate-level textual content and a key reference for training execs. Over a dozen unusual participants probe the most recent advancements in our wisdom of why humans age and the way the method works. those authoritative chapters will not be simply written for biologists ñ yet for gerontologists typically. Marks the 10th anniversary of the once a year assessment of Gerontology and Geriatrics.

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Additional info for Annual Review of Gerontology and Geriatrics, Volume 10, 1990: Biology of Aging

Sample text

Their weight-to-height ratio is very low. They average about 40 inches in height, but they usually weigh no more than 25 or 30 Ibs even as teenagers. The voice is thin and high pitched. Sexual maturation usually does not occur. They have a characteristic facial appearance with prominent eyes, a beaked nose, a "plucked-bird" appearance, and facial disproportion resulting from a small jaw and large cranium. The large balding head and small face give them an extremely aged appearance. The bones show distinctive changes, with frequent resorption of the clavicles and replacement by fibrous tissue.

Parker, J. W. 1971. Susceptibility of chromosomes from patients with Down's syndrome to 7, 12-dimethylbenz(a)anthracene induced aberations in vitro. International Journal of Cancer, 8, 303-310. Orgel, L. E. 1963. The maintenance of the accuracy of protein synthesis and its relevance to aging. Proceedings of the National Academy of Sciences of the USA, 49, 517521. Robakis, N. , & Wisniewski, H. M. 1987. Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic GENETIC DISEASES OF PREMATURE AGING 41 plaque amyloid peptides.

Rothstein, M. (1985). Age-related changes in enzyme levels and enzyme properties. In M. ), Review of biological research in aging (Vol. 1, p. 421). New York: Alan Liss. Rubner, M. (1908). Das problem der lebensdaver und seine beziebungen zum wachstum und ernabrung. Munich: Oldenbourg. Ryan, J. M. (1981). A comparison of the proliferative and replicative life span kinetics of cell cultures derived from monozygotic twins. In Vitro, 17, 20. Ryan, J. , & Cristofalo, V. J. (1974). Error accumulation and aging in human diploid cells.

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Annual Review of Gerontology and Geriatrics, Volume 10, 1990: Biology of Aging by Vincent J. Cristofalo PhD


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