By Yin-Tak Woo, David Y. Lai, Joseph C. Arcos
Chemical Induction of melanoma: Structural Bases and organic Mechanisms, quantity IIIB: Aliphatic and Polyhalogenated cancer causing agents covers environmentally and occupationally major cancer agents of commercial origins.
The publication discusses the structure-activity relationships, metabolism, and environmental value of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene insecticides, biphenyls, and similar aromatics. The textual content additionally describes the structure-activity relationships, metabolism, and environmental value of the halogenated phenoxy acids, fragrant ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and similar compounds. The structure-activity relationships, metabolism, and environmental value of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and comparable compounds thiocarbonyl compounds also are encompassed. The ebook additional tackles the structure-activity relationships, metabolism, and environmental value if fatty acids, detergents, and different surfactants with oncogenic power. The textual content then appears into the impact of chemical reactivity, molecular geometry, and metabolism on carcinogenic task.
Chemists, geneticists, and people curious about melanoma study will locate the booklet priceless.
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Additional resources for Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms
Theis3 8 , G. D. S t o n e r ,, M. B. Shimkin and E. K. Weisburger, Cancer R e s . 37, 2717 ( 1 9 7 7 ) . T o t a l dose over the 24-week p e r i o d (mmoles/kg). the h i g h e s t dose was l i s t e d . c For n e g a t i v e r e s u l t s , Not s i g n i f i c a n t b u t w i t h p - v a l u e c l o s e to 0 . 0 5 . * S i g n i f i c a n t l y h i g h e r than n e g a t i v e c o n t r o l s w i t h p < 0 . 0 5 . 1 Halogenated Linear Alkanes and Alkenes I 37 marginal activity. With the exception of tert-buty\ iodide (tested at a very low dose) and iodoethane, all iodoalkanes tested are active.
Among the 30 survivors 10 had liver nodules diagnosed histologically as early or established liver carcinomas. The details of the study and the type of control were not given. 3 ml/kg of a 50% solution of CC14 in corn oil. A low incidence of small hepatomas was observed in Buffalo strain rats of both sexes treated at the age of 24 or 52 weeks (236). The hepatocarcinogenicity of CC14 in Buffalo strain rats was enhanced by simultaneous administration of 3-methylcholanthrene (238). Japanese, Osborne-Mendel, and Wistar rats appeared to be considerably more susceptible to the hepatocarcinogenic action of CC14; their respective incidences of hepatocellular carcinomas were 80% (12/15), 62% (8/13), and 33% (4/12).
However, the doses administered (488 and 977 mg/kg/day for males; 538 and 1077 mg/kg/day for females) caused a high rate of early deaths so that an insufficient number of rats survived long enough to rule out the possibility of late-developing tumors. Three tetrahalomethanes (trichlorobromomethane, dibromodichloromethane, and tetrabromomethane) were tested by Rudali (233). 1 ml of either a 10% solution of trichlorobromomethane or dichlorodibromomethane or a 40% solution of tetrabromomethane for an unspecified period of time.
Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms by Yin-Tak Woo, David Y. Lai, Joseph C. Arcos