By D. Virgil Alfaro III MD, Peter E. Liggett MD, William F. Mieler MD, Hugo Quiroz-Mercado MD, Rama D. Jager MD MBA FACS, Yasuo Tano MD

ISBN-10: 0781738997

ISBN-13: 9780781738996

ISBN-10: 146987492X

ISBN-13: 9781469874920

A well known team of retina surgeons provides promising new advancements in age-related macular degeneration, with emphasis at the most vital advances long ago 5 years. content material addresses all points of administration, together with anatomy, body structure, and pathophysiology; imaging of the macula in age-related macular degeneration; prevention measures and therapy; remedy; and destiny instructions. Abundantly illustrated and fantastically equipped, this ebook serves as a good reference and textbook.

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Additional info for Age-related macular degeneration : a comprehensive textbook

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One study showed that the indocyanine green angiographic grading of CNV activity was correlated with the amount of immunohistochemical staining for VEGF in excised specimens (117). Injection of an anti-VEGF aptamer and of an anti-VEGF antibody fragment caused angiographic regression of CNV (129,130). The mean visual acuity still declined in a randomized trial looking at the effects of the anti-VEGF aptamer, suggesting that anti-angiogenic treatment may not be a sufficient treatment for CNV. 3 Ischemia as a potential cause of CNV in ARMD.

GENETIC FACTORS There is a higher risk for the development of late-age-related maculopathy in people with a positive family history (1, 2 and 3). This raises the possibility of finding a gene or genes that may be linked to macular degeneration. 24 occurs in older individuals who are unlikely to have parents or grandparents alive for comparative testing. Mutation of the Stargardt disease gene (ABCR) was found by Allikmets et al. (22) to be associated with ARMD (in particular the non-neovascular subtype), but this same association was not found by others (23,24).

Fine BS, Kwapien RP. Pigment epithelial windows and drusen: an animal model. Invest Ophthalmol Vis Sci. 1978;17:1,059-1,068. 55. Murata T, Nakagawa K, Khalil A, et al. The temporal and spatial vascular endothelial growth factor expression in retinal vasculogenesis of rat neonates. Lab Invest. 1996;74:68-77. 85. Tabatabay CA, D'Amico DJ, Hanninen LA, et al. Experimental drusen formation induced by intravitreal aminoglycoside injection. Arch Ophthalmol. 1987;105:826-830. 86. Lullmann-Rauch R. Experimentally induced lipidosis in cat retinal pigment epithelium.

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Age-related macular degeneration : a comprehensive textbook by D. Virgil Alfaro III MD, Peter E. Liggett MD, William F. Mieler MD, Hugo Quiroz-Mercado MD, Rama D. Jager MD MBA FACS, Yasuo Tano MD

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