By Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis Halliwell

ISBN-10: 0230554156

ISBN-13: 9780230554153

The receptor inspiration used to be some of the most influential principles in 20th-century medication since it may well account for the hugely particular results of substances at the physique. This booklet is the 1st to supply an old dialogue of its starting place, improvement, gradual popularity into pharmacology and next impression on sleek medication. It additionally considers the social context that stimulated the drug receptor's development., creating a invaluable contribution to the historical past and knowing of recent drugs.

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129 But such protestations fade 36 A Short History of the Drug Receptor Concept in comparison to the extensive usage Ehrlich made of his pictures to persuade his contemporaries of the truthfulness of his theory. Criticism allowed Ehrlich to reconstruct and enlarge his receptor concept, since his strategy focused on further investigating his opponents’ viewpoints and integrating newly obtained knowledge into his theory, saying that his colleagues’ counter-arguments would finally confirm the receptor concept.

85 After having elaborated the meaning of the ‘side-chains’ with the creation of a ‘side-chain theory’, it was a logical next step to investigate the specific nature of side-chains. The new term stood for the central position of the side-chains in Ehrlich’s new research strand. 86 In 1901, Ehrlich and Morgenroth, when deepening their research on this general topic, made some remarks on the ‘peculiarities of the receptor apparatus’. 87 As in the case of the antibodies or intermediate bodies, the structure of the receptors was analysed and classified.

Some receptors were common to different animal species, and one could find them in many organs. 93 All those with two or more binding sites belonged to the receptors of third order. Blood plasma was filled with a vast amount of receptors released into the bloodstream, which Ehrlich called ‘haptins’ (Haptine). 94 Finally, he approached what he called the ‘pluralistic point of view’ (plurimistischer Standpunkt). 95 Because receptors played a key role in metabolism, research on receptors was not only aimed at classifying different substances, but also at more or less indirectly shaping the character and activity of the receptors themselves.

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A Short History of the Drug Receptor Concept (Science, Technology and Medicine in Modern History) by Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis Halliwell


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